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Sodium Starch Glycolate Our customers can avail from us an assortment of Sodium Starch Glycolate that is the sodium salt of a carboxymethyl ether of starch, having a typical molecular weight of 500 000-11 000 000. Practically insoluble in water and in most organic solvents, it appears as very fine, white or off white, free flowing powder that is odorless or almost odorless.
Consisting of oval or spherical granules, 30-100 μm in diameter with some less-spherical granules ranging from 10-35 μm in diameter, it is primarily used a Disintegrant, Dissolution Aid, Suspending Agent.
The disintegration of Sodium Starch Glycolate takes place by rapid uptake of water followed by rapid and enormous swelling. Its disintegrant efficiency is unimpaired in the presence of hydrophobic excipients, such as lubricants unlike many other disintegrants. Even if the tablet compression pressure is increased, it does not appear to have an effect on the disintegration time.
Application:
- Widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations.
- It is recommended to use in tablets prepared by either direct-compression or wet granulation processes.
- Used as a suspending vehicle
The recommended concentration in a formulation is 2-8%, with the optimum concentration about 4% although in many cases 2% is sufficient.
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